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Medicinal Chemistry - CBMS306

Medicinal chemistry is the application of chemistry to the discovery, design and synthesis of new drugs. This unit is of value to all molecular sciences and medical sciences students. The central core of the unit is the description of methods used for the discovery of new drugs, how these are modified to produce more active compounds, transportation to and from their points of action and how they are cleared from the body. Topics include: the structure and function of biological targets (proteins and DNA); sources of new drugs from nature; and lead generation and methods of lead modification to make more active, selective or less toxic drugs. This is followed by a study of structure-activity relationship methods; pharmacokinetics, drug metabolism and prodrugs, and chemical genetics. Case studies are also provided, including antibacterial and anticancer agents, and nucleic acid therapies. The theory is complemented by a discovery-based laboratory project incorporating synthetic chemistry, spectroscopic methods, bioassays and computational chemistry to elucidate the essential structural features necessary for the sulfonamide class of antibacterial agents.

Credit Points: 3
When Offered:

S1 Day - Session 1, North Ryde, Day

Staff Contact(s): Professor Peter Karuso

6cp in CBMS units at 200 level or above including (CBMS203 or CBMS204Prerequisite Information


NCCW(s): CBMS342
Unit Designation(s):

Medical Sciences


Unit Type:
Assessed As: Graded
Offered By:

Department of Molecular Sciences

Faculty of Science and Engineering

Course structures, including unit offerings, are subject to change.
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